Arisun chempharm Co., Ltd.

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Active Pharmaceutical Intermediates In Drugs , Pharmaceutical Fine Chemicals

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Good quality Pygeum Africanum Extract for sales
Good quality Pygeum Africanum Extract for sales
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Active Pharmaceutical Intermediates In Drugs , Pharmaceutical Fine Chemicals

China Active Pharmaceutical Intermediates In Drugs , Pharmaceutical Fine Chemicals supplier

Large Image :  Active Pharmaceutical Intermediates In Drugs , Pharmaceutical Fine Chemicals

Product Details:

Place of Origin: Xi`an
Brand Name: ARS
Certification: ISO, HACCP, KOSHER
Model Number: ARS20-001

Payment & Shipping Terms:

Minimum Order Quantity: 1Kg
Price: Negotiation
Packaging Details: 1kg/bag or small package as costomer's requirement.
Delivery Time: Prompt after your payment
Payment Terms: L/C, T/T, Western Union
Supply Ability: 50Kg/month
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Detailed Product Description
CAS No: 33069-62-4 Grade Standard: Cosmetic Grade
Form: Crystalline Powder Specification: 99% HPLC
Function: Anticancer Purity: 99%min
Color: White Product Name: Paclitaxel

Pharmaceutical Intermediates Paclitaxel API pure Synthesis paclitaxel 99%

 

1. Production Description

 

Natural Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it 'taxol'. When it was developed commercially by Bristol-Myers Squibb (BMS) the generic name was changed to 'paclitaxel' and the BMS compound is sold under the trademark 'TAXOL'. In this formulation, paclitaxel is dissolved in Cremophor EL and ethanol, as a delivery agent.

 

Tests Standards Results
Appearance white powder Wcrystalline powder.hite,
Identification A:IR absorption Complies Complies
B:UV absorption Complies Complies
C:TLC Complies Complies
Melting point 168~172°C 169.0~170.9°C
Water Not more than0.5% 0.08%
Related substance ImpurityJ(chloroacetanilide)not more than 10 ppm 2ppm
Impurity K(4-aminophenol)not more than 50 ppm 15 ppm
Impurity F(4-nitrophenol)not more than 0.05% Not detected
any other impurity not more than 0.05% 0.01%
Total of other impurities not more than 0.1% 0.02%
Residue on ignition Not more than 0.1% 0.05%
Chloride Not more than 0.014% Less than 0.014%
Sulfate Not more than 0.02% Less than 0.02%
Sulfide Conforms Conforms
Heavy metals Not more than 0.001% Less than 0.001%
Free p-aminophenol Not more than 0.005% Less than 0.005%
Limit of P-chloroacetanilide Not more than 0.001% Less than 0.001%
Readily carbonizable substances Conforms Conforms
Residual solvents Residual content of acetic acid is limited 0.08%
by the test of loss on dryingnot more than0.5%
Assay(anhydrous basis) 99.0~101.0% 99.60%
Conclusion: Complies with USP34/ BP2011

 

2. Function

 

1. Paclitaxel has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.

3. Paclitaxel is a mitotic inhibitor drup used in the treatment of cancer.
4. Paclitaxel is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.

 

3. Application

 

1. Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes .

2. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis.

 

4. Featured Advantage

 

1. 5000Kg per mouth production capability of plant extracts.

2. Prompt respeonse to your inquiries. 7*24 Customer Service.

3. Flexible Payment Terms: L/C, T/T,DP,DA, OA.

4. Factory Price, profit comes from government tax rebates.

Contact Details
Arisun chempharm Co., Ltd.

Contact Person: Wei

Tel: +8615901935043

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