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Raw Pharmaceutical Intermediates , Anticancer Drugs Synthesis White Crystallize Powder

Basic Information
Place of Origin: Xi`an
Brand Name: ARS
Certification: ISO, HACCP, KOSHER
Model Number: ARS20-001
Minimum Order Quantity: 1kg
Price: Negotiation
Packaging Details: 1kg/bag; Small package as costomer's requirement.
Delivery Time: Prompt after your payment
Payment Terms: L/C, T/T, Western Union
Supply Ability: 50Kg/month
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Detail Information
Ash: ≤5.0% 10-Deacetyl Paclitaxel Propyl Analog: ≤0.4%
10-Deacetyl-19-hydroxybaccatin III: ≤1.0% Moisture: ≤2.0%
10-Deacetyl Paclitaxel: ≤1.0% Appearance: White Crystallize Powder
Application: Pharmaceutical Raw Intermediates Type: API

Product Description

Pharmaceutical Intermediates 99% 10-Deacetylbaccatin III CAS 32981-86-5

1. Production Description

10-Deacetylbaccatin III (10-DAB) can be gained from the leaves of yew trees and it is used as starting materials for numerous partial syntheses.
 
Paclitaxel is a monomer diterpenoid compound extracted from Natural Plant Paclitaxel bark, is a kind of complex secondary metabolites, is currently understood only a drug can promote microtubule polymerization and stability of microtubules have been aggregated. Isotope tracing showed that paclitaxel was bound only to polymerized microtubules, not to the polymerized tubulin two. Cell contact paclitaxel after the accumulation of a large number of microtubules in cells, which interfere with microtubule accumulation of various cellular functions, especially the cell division stop in mitosis, blocking the normal cell division.
 
Analysis Specification Results
Assay(HPLC) ≥98% 99.50%
10-Deacetyl-19-hydroxybaccatin III ≤1.0% 0.16%
10-deacetyl-2-debenzoyl-2-tigloybaccatin III ≤1.0% 0.13%
10-Deacetyl paclitaxel ≤1.0% Negative
10-Deacetyl paclitaxel ethyl analog ≤0.3% 0.1
10-Deacetyl paclitaxel propyl analog ≤0.4% 0.09
10-Deacetyl paclitaxel cephalomannine ≤0.5% 0.05
Appearance White crystallize powder Complies
Ash ≤5.0% 2.30%
Moisture ≤2.0% 1.20%
Pesticides Negative Complies
Solvent residual ≤1.5% 0.56%
Heavy metals ≤10ppm Complies
Pb ≤1.0ppm Complies
As ≤2.0ppm Complies
Hg ≤0.2ppm Complies
Odor Characteristic Complies
Particle size 100%through 80 mesh Complies
Solubility Insoluble in water Complies
Soluble in ethanol
Specific Optical Rotation -40.0°~ -45.0° -43.3°
Microbioiogical:
Total of bacteria ≤1000cfu/g Complies
Fungi ≤100cfu/g Complies
Salmgosella Negative Complies
Coli Negative Complies
Storage Store in cool & dry place. Do not freeze.
Keep away from strong light and heat.
Shelf life 2 years when properly stored

2. Function:

1. Treatment of uterine cancer and breast cancer.
Introduction
2. An intermediate in the synthesis of paclitaxel and its derivatives.
3. 10-Deacetylbaccatin III (10-DAB) can be gained from the leaves of yew trees and it is used as starting materials for numerous partial syntheses.
 
3. Application 
 
1. For the synthesis of anticancer drugs such as docetaxel
 
4. Featured Advantage
 
1. Quality guarantee: International Authorized Third-Party Test for the products you need.
2. Selecting raw materials strictly;
3. HACCP, ISO, KOSHER,QC certifications available.
4. On time delivery, no OTD complaint or claim

Contact Details
Wei

Phone Number : +8615901935043